Heparin sodium CAS 9041-08-1

Heparin sodium is anticoagulant drug, iri mucopolysaccharide substance.Ndiyo sodium munyu weglucosamine sulfate yakatorwa kubva mumatumbo emucosa yenguruve, mombe nemakwai.pakati.Heparin sodium ine mabasa ekudzivirira kuunganidzwa kweplatelet uye kuparadzwa, kurambidza kutendeuka kwefibrinogen kuita fibrin monomer, kurambidza kuumbwa kwethromboplastin uye kuramba kuumbwa kwethromboplastin, kudzivirira kutendeuka kweprothrombin kuita thrombin uye antithrombin.

Heparin sodium inogona kunonoka kana kudzivirira ropa coagulation zvese mu vitro uye mu vivo.Maitiro ayo ekuita akaomesesa zvakanyanya uye anokanganisa akawanda malink mukuita coagulation.Mabasa ayo ndeaya: ①Inhibit kuumbwa uye kushanda kwethromboplastin, nokudaro kudzivirira prothrombin kubva pakuva thrombin;②Munzvimbo dzakakwirira, inogona kuvharidzira thrombin uye zvimwe zvinokonzera coagulation, kudzivirira fibrinogen kubva pakuva fibrin Protein;③ inogona kudzivirira kuunganidzwa uye kuparadzwa kweplatelet.Mukuwedzera, iyo anticoagulant mhedzisiro ye sodium heparin ichiri kuenderana neiyo yakaipa chaja sulfate radical mumorekuru wayo.Positively charged alkaline substances senge protamine kana toluidine blue inogona kuita neutralize yayo negative charge, saka inogona kuvharisa anticoagulant yayo.coagulation.Nekuti heparin inogona kumisa uye kuburitsa lipoprotein lipase mumuviri, hydrolyze triglyceride uye yakaderera-density lipoprotein mumachylomicrons, saka ine zvakare hypolipidemic athari.

Heparin sodium inogona kushandiswa kurapa acute thromboembolic chirwere, kuparadzirwa intravascular coagulation (DIC).Mumakore achangopfuura, heparin yakawanikwa iine mhedzisiro yekubvisa ropa lipids.Jekiseni remutsinga kana jekiseni rakadzika remumuscular (kana jekiseni rezasi), 5,000 kusvika 10,000 mayunitsi nguva imwe neimwe.Heparin sodium haina muchetura uye inongoerekana yabuda ropa ndiyo njodzi inonyanya kukosha yeheparin overdose.Isingashande nemuromo, inofanirwa kupihwa nejekiseni.Intramuscular jekiseni kana subcutaneous jekiseni rinonyanya kutsamwisa, dzimwe nguva allergic reactions inogona kuitika, uye overdose inogona kutokonzera kusungwa kwemwoyo;dzimwe nguva kupera kwebvudzi kwenguva pfupi uye manyoka.Mukuwedzera, inogona kuramba ichikonzera kuputsika kwepamuviri.Kushandiswa kwenguva refu dzimwe nguva kunogona kukonzera thrombosis, iyo inogona kunge iri mhedzisiro yeanticoagulase-III kupera.Heparin sodium inopesana nevarwere vane tsika yekubuda ropa, chiropa chakanyanya uye kusakwana kwerenal, hypertension yakanyanya, hemophilia, intracranial hemorrhage, peptic ulcer, vakadzi vane pamuviri uye postpartum, visceral tumors, trauma uye kuvhiyiwa.